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KMID : 0359720230410040306
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Journal of the Korean Neurological Association
2023 Volume.41 No. 4 p.306 ~ p.309
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An Acute Metabolic Encephalopathy, Lactic Acidosis and Stroke-like Episodes Syndrome Patients with Hyperperfusion Responsive to Steroid Treatment
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Song Kwan-Ju
Choi Tae-Hyeon
Kim Ki-Jeong
Ha Sang-Hee
Kim Bum-Joon
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Abstract
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Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a genetic disorder caused by mutation in mitochondrial DNA. Patients with stroke-like episodes show restrictive lesions in diffusion weighted image, whereas magnetic resonance angiography images show both vasodilation or vasoconstriction. Vasodilation may lead to hyperperfusion and cerebral edema, which may worsen clinical outcome. Here, we report a 25-year-old male patient diagnosed as MELAS, who presented with stroke-like episodes and seizures and showed cerebral edema with vasodilation which was normalized after steroid treatment.
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KEYWORD
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MELAS syndrome, Cerebral blood flow, Steroids
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